3D printing tablets for individual pediatric patients: development of furosemide and sildenafil tablets

A clear unmet medical need exists for pediatric-centered drug formulations. Currently, it is often still necessary to either manipulate a marketed drug before it can be administered to a child, or to prepare an extemporaneous preparation by the pharmacist. As a highly flexible production technique, 3D printing can provide in this unmet need.

In this presentation, the product development of two active pharmaceutical ingredients, namely furosemide and sildenafil, will be presented.

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Enabling Novel Pharmaceutical Therapies through 3D-Printing

Aprecia continues its leadership position in the pharmaceutical application of 3D-Printing. Aprecia will be launching its two new platforms later this year that will provide additional benefits in early development FIH clinical as well as small and large scale commercial production. In this presentation, Aprecia will discuss the flexibility and precision these platform provide in delivering novel products to the market.

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Stress-relieving: printing personalized cortisol for patients with adrenal insufficiency.

The treatment goal for patients with adrenal insufficiency (AI) is to mimic physiological cortisol plasma concentrations. The current cortisol replacement therapies are suboptimal due to their drug release profile, fixed-dose character and the inability to cover nocturnal cortisol plasma concentrations. There is a high inter-individual variability in the cortisol need within this patient group, which comes with the unmet need for personalized cortisol formulations. 3D printing is a suitable technology for manufacturing oral dosage forms which allows us to easily adjust the drug dose and release profile based on patient needs. The aim of this research is to develop novel tailor-made 3D printed hydrocortisone formulations covering the daily as well as nocturnal physiological cortisol plasma concentrations.

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A personalised dosing strategy using 3D-printing to facilitate zolpidem withdrawal therapy

The long-term use of benzodiazepine receptor agonists (BZRAs) is associated with multiple side effects, such as increased sedation, hangover or an elevated risk of dependency and abuse. Unfortunately, the long-term use of BZRAs is reaching worrying intake rates, and therefore, the need for action is high. It was demonstrated already that the overall willingness of patients for deprescription increased when a slow dose reduction scheme with the possibility for dose increase, if needed, is employed.

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Manipulations and age-appropriateness of oral medications in pediatric oncology and neurology patients in Sweden

Mattias Paulsson

Need for personalized dosage forms. Due to the lack of age-appropriate formulations for children, healthcare professionals and caregivers frequently manipulate dosage forms to facilitate oral administration and obtain the required dose. In this presentation, drug manipulation and age-appropriateness of oral medications for pediatric oncology and neurology patients are summarised with the aim of identifying the therapeutic needs for personalized dosage forms.

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Industrial applications of 3D powder bed printed lactose tablets: From laboratory scale to production.

korinde van den heuvel

Since the approval of Spritam in 2015, various proof of concepts on 3D printed tablets have been published by the academic world. They proofed that 3D printing is a versatile technique capable of printing tablets in line with pharmaceutical standards. The next step for this technique is to convert the academic proof into industrial applications.

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Options to implement digital printing of medicines in clinical practice

The advantages of digital printing of medicines are obvious. With this technology, it is now possible to flexibly print the individually necessary and prescribed dose on demand. Several active ingredients can also be freely combined – compounded. The number of tablets a patient takes decreases, adherence and compliance increase. The process is also much more efficient and saves resources than pressing or encapsulating drugs.

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Printing of Medicines – What do Hospital Pharmacists expect from Hard- and Software Vendors

torsten-hoppe-tichy

Printing of individualized medicines is very interesting option for hospital pharmacists. Up to now those individualized medicines are often produced in the patient group of children. Dosages have to be adapted, alternative dosage forms have to be developed as many of those patients are not able to swallow tablets or capsules. Printing those medicines on orodispersable films with some kind of inkjet printer could be very helpful.

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