February 2023, Mikrocentrum, Veldhoven, The Netherlands, part of 3D Medical Printing Series
#3dpharma
This post shows an overview of the presentations given during this edition. Some speakers have given permission to watch the presentation and/or download the PDF of the presentation. Click on the right link.
Continue reading “3D Pharma Printing Conference 2022”
A clear unmet medical need exists for pediatric-centered drug formulations. Currently, it is often still necessary to either manipulate a marketed drug before it can be administered to a child, or to prepare an extemporaneous preparation by the pharmacist. As a highly flexible production technique, 3D printing can provide in this unmet need.
In this presentation, the product development of two active pharmaceutical ingredients, namely furosemide and sildenafil, will be presented.
Continue reading “3D printing tablets for individual pediatric patients: development of furosemide and sildenafil tablets”
Aprecia continues its leadership position in the pharmaceutical application of 3D-Printing. Aprecia will be launching its two new platforms later this year that will provide additional benefits in early development FIH clinical as well as small and large scale commercial production. In this presentation, Aprecia will discuss the flexibility and precision these platform provide in delivering novel products to the market.
Continue reading “Enabling Novel Pharmaceutical Therapies through 3D-Printing”
In this presentation I would like to share with you the steps we at TNO and our partners are taking towards practical application of 3D pharmaprinting, and give an insight in how we envision to tackle the challenges still ahead. A presentation by Anton Aulbers, Senior consultant 3D Pharma printing at TNO.
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The treatment goal for patients with adrenal insufficiency (AI) is to mimic physiological cortisol plasma concentrations. The current cortisol replacement therapies are suboptimal due to their drug release profile, fixed-dose character and the inability to cover nocturnal cortisol plasma concentrations. There is a high inter-individual variability in the cortisol need within this patient group, which comes with the unmet need for personalized cortisol formulations. 3D printing is a suitable technology for manufacturing oral dosage forms which allows us to easily adjust the drug dose and release profile based on patient needs. The aim of this research is to develop novel tailor-made 3D printed hydrocortisone formulations covering the daily as well as nocturnal physiological cortisol plasma concentrations.
Continue reading “Stress-relieving: printing personalized cortisol for patients with adrenal insufficiency.”
The long-term use of benzodiazepine receptor agonists (BZRAs) is associated with multiple side effects, such as increased sedation, hangover or an elevated risk of dependency and abuse. Unfortunately, the long-term use of BZRAs is reaching worrying intake rates, and therefore, the need for action is high. It was demonstrated already that the overall willingness of patients for deprescription increased when a slow dose reduction scheme with the possibility for dose increase, if needed, is employed.
Continue reading “A personalised dosing strategy using 3D-printing to facilitate zolpidem withdrawal therapy”
Need for personalized dosage forms. Due to the lack of age-appropriate formulations for children, healthcare professionals and caregivers frequently manipulate dosage forms to facilitate oral administration and obtain the required dose. In this presentation, drug manipulation and age-appropriateness of oral medications for pediatric oncology and neurology patients are summarised with the aim of identifying the therapeutic needs for personalized dosage forms.
Continue reading “Manipulations and age-appropriateness of oral medications in pediatric oncology and neurology patients in Sweden”
Since the approval of Spritam in 2015, various proof of concepts on 3D printed tablets have been published by the academic world. They proofed that 3D printing is a versatile technique capable of printing tablets in line with pharmaceutical standards. The next step for this technique is to convert the academic proof into industrial applications.
Continue reading “Industrial applications of 3D powder bed printed lactose tablets: From laboratory scale to production.”
The advantages of digital printing of medicines are obvious. With this technology, it is now possible to flexibly print the individually necessary and prescribed dose on demand. Several active ingredients can also be freely combined – compounded. The number of tablets a patient takes decreases, adherence and compliance increase. The process is also much more efficient and saves resources than pressing or encapsulating drugs.
Continue reading “Options to implement digital printing of medicines in clinical practice”
Printing of individualized medicines is very interesting option for hospital pharmacists. Up to now those individualized medicines are often produced in the patient group of children. Dosages have to be adapted, alternative dosage forms have to be developed as many of those patients are not able to swallow tablets or capsules. Printing those medicines on orodispersable films with some kind of inkjet printer could be very helpful.
Continue reading “Printing of Medicines – What do Hospital Pharmacists expect from Hard- and Software Vendors”