Manipulations and age-appropriateness of oral medications in pediatric oncology and neurology patients in Sweden

Need for personalized dosage forms. Due to the lack of age-appropriate formulations for children, healthcare professionals and caregivers frequently manipulate dosage forms to facilitate oral administration and obtain the required dose. In this presentation, drug manipulation and age-appropriateness of oral medications for pediatric oncology and neurology patients are summarised with the aim of identifying the therapeutic needs for personalized dosage forms.

This presentation demonstrates problems and therapeutic needs regarding oral dosage forms in treatment of children in hospitals and to some extent also at home. Expertise in formulation design, new manufacturing technologies, and patient-centered information are needed to address age-appropriate formulations for children.

A presentation by Mattias Paulsson, Deputy Chief Pharmacist, Affiliated researcher at Uppsala university children’s hospital.


Question 1: What drives you?
To increase the awareness of challenges and potential risks in pediatric medication handling in the clinic and at home.

Question 2: Why should the delegate attend your presentation?
In my presentation I put the value of additive manufacturing / 3D-printing in a clinical context. I share knowledge of pediatric patients’ need as well as challenges in health care establishments from a pharmacists perspective.

Question 3: What emerging technologies / trends do you see as having the greatest potential in the short and long run?
GMP validated pharmacoprinting devices are now emerging and for the long run we need to have easy access to a wide assortment of active pharmaceutical ingredient through pharmacoprinting.

Question 4: What kind of impact do you expect them to have?
Access to individualised doses in hospital.

Question 5: What are the barriers that might stand in the way?
Mainly regulatory challenges.

About Mattias Paulsson
Mattias Paulsson obtained his pharmacist degree at Uppsala University, Sweden, and his PhD (Pharmaceutics) in 2001.
Dr. Paulsson has held positions as formulation scientist at both Cederroth International and Fresenius Kabi. He has been heading the extemporaneous compounding unit of Uppsala University Hospital, preparing radio¬pharmaceuticals, chemotherapy and other aseptically prepared medications as well as managing the clinical trials unit. He has been a qualified person and held positions with GMP-responsibility for compounding units at some Swedish hospitals.
He is involved in both undergraduate and post graduate training of pharmacists at Uppsala University.

About Uppsala university children’s hospital
Akademiska sjukhuset, Uppsala University Hospital, is Sweden’s oldest University Hospital. The first department was established as early as 1708.

Mattias Paulsson is speaker at the 2022 edition of the 3D Pharma Printing Conference.

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