3D powder bed printing with lactose: a showcase

korinde van den heuvel

by Korinde van den Heuvel, Senior Product Developer, DFE Pharma

3D printing offers huge potential benefits in pharmaceutical manufacturing, like creating fast and reliable wide dosed dosage forms for clinical use and ability to tailor dose in dosage forms for specific user groups. In order to embrace this new world of opportunities, there is a need for thorough understanding of the powder physics of the materials, processes and techniques involved. Powder bed printing, which has been used to develop Spritam, is arguably the best method for pharmaceutical manufacturing.

Powder physics like, flowability, wettability and consolidation of the blend are critical material attributes for powder bed printing and will impact the tablet functionality like hardness, disintegration and friability. Limited information is available on excipient selection in relationship to functionality in the dosage form in literature.

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