February 2023, Mikrocentrum, Veldhoven, The Netherlands, part of 3D Medical Printing Series
#3dpharma
In this presentation I would like to share with you the steps we at TNO and our partners are taking towards practical application of 3D pharmaprinting, and give an insight in how we envision to tackle the challenges still ahead. A presentation by Anton Aulbers, Senior consultant 3D Pharma printing at TNO.
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The treatment goal for patients with adrenal insufficiency (AI) is to mimic physiological cortisol plasma concentrations. The current cortisol replacement therapies are suboptimal due to their drug release profile, fixed-dose character and the inability to cover nocturnal cortisol plasma concentrations. There is a high inter-individual variability in the cortisol need within this patient group, which comes with the unmet need for personalized cortisol formulations. 3D printing is a suitable technology for manufacturing oral dosage forms which allows us to easily adjust the drug dose and release profile based on patient needs. The aim of this research is to develop novel tailor-made 3D printed hydrocortisone formulations covering the daily as well as nocturnal physiological cortisol plasma concentrations.
Continue reading “Stress-relieving: printing personalized cortisol for patients with adrenal insufficiency.”
The advantages of digital printing of medicines are obvious. With this technology, it is now possible to flexibly print the individually necessary and prescribed dose on demand. Several active ingredients can also be freely combined – compounded. The number of tablets a patient takes decreases, adherence and compliance increase. The process is also much more efficient and saves resources than pressing or encapsulating drugs.
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Pharmacy compounding, local medicine production, close to the patient and adapted to individual needs, has been around for many decades but the techniques used have not changed much over the years. A more innovative option is the production of 3D printed tablets, and benchtop FDM printers would fit in any community or hospital pharmacy.
Continue reading “Bringing 3D printing to community pharmacy”
Interview with Beatriz Pereira, University of Central Lancashire, for JakajimaTV hosted by Pieter Hermans. Current healthcare follows an ‘one size fits all’ approach, and it is associated with high variations in treatment outcomes, due to the high interindividual variability.
Continue reading “3D printing of modular ‘polypills’ for personalised therapy”