Stress-relieving: printing personalized cortisol for patients with adrenal insufficiency.

The treatment goal for patients with adrenal insufficiency (AI) is to mimic physiological cortisol plasma concentrations. The current cortisol replacement therapies are suboptimal due to their drug release profile, fixed-dose character and the inability to cover nocturnal cortisol plasma concentrations. There is a high inter-individual variability in the cortisol need within this patient group, which comes with the unmet need for personalized cortisol formulations. 3D printing is a suitable technology for manufacturing oral dosage forms which allows us to easily adjust the drug dose and release profile based on patient needs. The aim of this research is to develop novel tailor-made 3D printed hydrocortisone formulations covering the daily as well as nocturnal physiological cortisol plasma concentrations.

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A personalised dosing strategy using 3D-printing to facilitate zolpidem withdrawal therapy

The long-term use of benzodiazepine receptor agonists (BZRAs) is associated with multiple side effects, such as increased sedation, hangover or an elevated risk of dependency and abuse. Unfortunately, the long-term use of BZRAs is reaching worrying intake rates, and therefore, the need for action is high. It was demonstrated already that the overall willingness of patients for deprescription increased when a slow dose reduction scheme with the possibility for dose increase, if needed, is employed.

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